910463-68-2Semaglutide Adipotide859216-15-2

Semaglutide is a long-acting analogue of human glucagon like peptide-1 (GLP-1), with 94% of the human GLP-1 sequence. It has a high GLP-1 receptor affinity (0.38 0.06 nM) by substitution of two amino acids and derivatization at lysine 26. Semaglutide reduces blood sugar by stimulating insulin release, while inhibiting glucagon secretion, delaying gastric emptying, and reducing food intake through central appetite suppression, thereby achieving the effect of lowering blood sugar and weight